Mortezaee K, Salehi E, Mirtavoos-Mahyari H, et al. Mechanisms of apoptosis modulation by curcumin: Implications for cancer therapy. J Cell Physiol. 2019;234(8):12537-12550. doi:10.1002/jcp.28122 This starts as a powder blend of vitamin C and ferulic acid—just sprinkle a bit into your serum of choice and you'll bring loads of antioxidant benefits into the base formula. Basically you can make any serum a powerhouse vitamin C option with this powder!

Bone broth boasts many benefits for gut healing, joint repairing, sleep, and more. Pressed for time or want a variety? These recipes will hit the spot. READ MORE These may include active ingredients like alpha-hydroxy acids (AHAs), beta-hydroxy acids (BHAs), retinol, vitamin C, and soothing botanical extracts like green tea, cucumber, and tea tree. Editor Tip: It has a slight floral scent that makes applying this serum a luxurious, almost spa-like experience. If you're sensitive to fragrance, you can avoid this or do a small patch test. Panahi Y, Khalili N, Sahebi E, et al. Curcuminoids modify lipid profile in type 2 diabetes mellitus: A randomized controlled trial. Complement Ther Med. 2017;33:1-5. doi:10.1016/j.ctim.2017.05.006 Always apply it on clean skin, right after washing. (This way, it can penetrate the skin cells.) You'll want to let it dry, as adding something on right after could potentially deactivate the vitamin C. Once dry, follow it with your daily face moisturizer and the rest of your skin care routine.Recently, especial attention has been paid to turmeric due to its antioxidant activities which are carried through direct scavenging of oxygen radicals and stimulating antioxidant responses by nuclear factor erythroid 2-related factor 2 (Nrf2) activation. That feature, besides the favorable outcomes on the endothelial function and the inflammatory state of the tissue and plasma, indicated that it was helpful for the treatment of diabetic microangiopathy potentially [ 63]. The bioactive components present in turmeric volatile oil include tumerone that is reported to be effective against carcinogenesis. The previous investigation indicated that turmeric had distinctive antioxidant potential [ 64]. Curcumin removed turmeric oleoresin which is the resource material for the production of curcumin and contains oil, resin, and nonextractable curcumin. During a lab study, various fractions and turmeric oil exhibited considerable antimutagenic and antioxidant ability [ 28]. Curcumin at a concentration of 200 mg/kg body weight of female Wistar rats appreciably reduced the oxidative damage in the hippocampus of rats when exposed to the organophosphate pesticides parathion; thus, it is an alternative to prevent neurodegenerative damage after pesticide exposure [ 65]. molecular structures of curcumin: (1) demethoxycurcumin, (2) bisdemethoxycurcumin, (3) curcumin glucuronide, (4) monodemethylcurcumin, (5) curcumin monoglucoside, (6) curcumin diglucoside, (7) Keto-curcumin, and (8) allyl curcumin (obtained and modified from Open Chemistry Database, National Center for Biotechnology Information, and PubChem Substance Database; https://pubchem.ncbi.nlm.nih.gov/substance). 5. Anticancer Perspectives However, most of these novel products seem to be safe. Solid lipid curcumin particle formulation showed no adverse effects in patients with osteosarcoma and healthy peoples [ 134]. Poly(N-isopropylacrylamide) delivery system, as another novel system which transports curcuminoids to the brain nasally, showed no toxicity [ 135]. Dipeptide nanoparticles of curcumin are safe, too. Dipeptide is synthesized from amino acids α, β–dehydro phenylalanine and methionine, which are safe and capable of being decomposed in nature [ 136]. New curcumin analogues are another recently used option in medicine. According to in vivo studies, they showed no toxicities [ 137]. Moreover, nanoparticles of curcumin-loaded human serum albumin showed no toxicity during intravenous use in tumor xenograft HCT116 models [ 138]. In some cases, modernized formulation of curcumin seems to be safer than conventional ones. Results of a study on a novel intravenously injectable curcumin revealed that rabbits in curcumin nanosuspension group developed local irritation and phlebitis risks and erythrocyte hemolysis lesser than those in curcumin solution group [ 139]. 10. Conclusion Sodium polyacrylate is used to give a nice texture to the serum. It is a film-forming agent that gives your skin a smooth feeling. Turmeric Dark Spot Corrector Serum | Benefits

In prehistoric times, C. longa has been utilized for the management of numerous illnesses [ 32, 33]. Turmeric and its ingredient can be considered as multitargeted phytochemicals for cancer treatment. For example, apoptosis, autophagy, and cell cycle arrest can be affected by their use [ 34]. There are so many signaling pathways (e.g., p53, Ras, phosphoinositide 3- kinase, AKT, Wnt/ β-catenin, and mammalian target of rapamycin) that are anticancer targets of curcumin [ 35, 36]. Also, regulation of microRNAs network expression is modified by turmeric [ 37]. It should be noted that histone deacetylases activity is inhibited by curcumin, according to in vitro and in vivo studies [ 38]. 5.1. Colorectal Cancer A more potent option, this combines 20% Bis-Glyceryl Ascorbate and a 10% AHA blend. This will provide serious brightening, exfoliating, and smoothing properties. Consider this your ideal formula if you have breakouts, acne marks, texture concerns, or wrinkles. However, if you have sensitive skin—this can be irritating, so I recommend avoiding it.

The Pilgrim Vitamin C Night Serum has an anti-aging formula designed for dry and combination skin types. It contains vitamin C that acts as a powerful antioxidant to prevent free radical damage, while vitamin E protects the skin from sun damage. Dark spots: The main objective of the serum is to treat dark spots and make them even. It was made for the sole purpose of treating dark spots. Turmeric has been proven to be an active agent in reducing dark spots.