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Figures

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However, the introduction of the domestic cat to the Americas from Europe and Africa accompanied by T. gondii strains adapted to the domestic cat provided conditions for the emergence for the first time of toxoplasmosis as a major zoonotic disease in those areas,” he said. Dewey FE, Murray MF, Overton JD, Habegger L, Leader JB, Fetterolf SN, et al. Distribution and clinical impact of functional variants in 50,726 whole-exome sequences from the DiscovEHR study. Science. 2016;354(6319):aaf6814. pmid:28008009Wood, Mikael (21 December 2019). "In 'Cats,' 'Memory' is a 'popera' furball, but don't blame Jennifer Hudson". Los Angeles Times. Archived from the original on 1 January 2020 . Retrieved 2 January 2020. To the left of the figure panels, constraint groups are labeled with pLI ranges shown below in braces. Below the pLI ranges are the number of genes found in each constraint group. SNV values show the total number of SNVs of a particular impact that belong to each constraint group. (a) Observed percentage differences from expected values for per kb SNV density. Light colored rectangles represent the 95% confidence intervals for the expected values. Confidence intervals were calculated using 10,000 permutations (methods). (b) The percentage of SNVs of different impacts and constraint groups across various MAF intervals. (c) Observed percentage differences from expected values for the fraction of SNVs in a singleton state (allele count of 1). Light colored rectangles represent the 95% confidence intervals for the expected values, generated from 10,000 permutations. (d) Pairwise SNV count contrasts between gene constraint groups and SNVs of the same impact. “*” indicates a p-value < 0.05 and “**” indicates a p-value < 0.001. (e) Pairwise singleton count contrasts between gene constraint groups and SNVs of the same impact. Asterisks above odds ratio values indicate the same values as (d). D'Alessandro, Anthony (2 November 2018). "Royal Ballet Principal Dancer Francesca Hayward Joins Universal-Working Title's 'Cats' ". Deadline Hollywood. Archived from the original on 3 November 2018 . Retrieved 2 November 2018.

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