Hypokalaemia (resulting from long-term laxative abuse) potentiates the action of cardiac glycosides and interacts with antiarrhythmic medicinal products, with medicinal products which induce reversion to sinus rhythm (e.g. quinidine) and with medicinal products inducing QT-prolongation. Concomitant use with other medicinal products inducing hypokalaemia (e.g. diuretics, adrenocorticosteroids and liquorice root) may enhance electrolyte imbalance New medications or inadequate physical activity are both factors that contribute to constipation after surgery. Your physician may recommend a laxative if you are recovering from surgery and having problems with constipation. ACTIVE INGREDIENTS: Each SENOKOT ® tablet contains 8.6 mg standardized sennosides from natural senna. In a 90-day rat study, senna pods were administered at dose levels from 100 mg/kg up to 1,500 mg/kg. The tested drug contained 1.83 % sennosides A-D, 1.6 % potential rhein, 0.11 % potential aloe-emodin and 0.014 % potential emodin. In all groups epithelial hyperplasia of the large intestine of minor degree was found and was reversible within the 8-week recovery period. The hyperplastic lesions of the forestomach epithelium were reversible as well. Dose-dependent tubular basophilia and epithelial hypertrophy of the kidneys were seen at a dose of, or greater than 300 mg/kg per day without functional affection. These changes were also reversible. Storage of a brown tubular pigment led to a dark discoloration of the renal surface and still remained to a lesser degree after the recovery period. No alterations were seen in the colonic nervous plexus. A no-observable-effect-level (NOEL) could not be obtained in this study. NON-MEDICINAL INGREDIENTS: Corn starch, glycerin, hydroxypropyl cellulose, hypromellose, magnesium stearate, microcrystalline cellulose, iron oxide red, titanium dioxide.

Stomach/ abdominal pain or cramping, nausea, diarrhea, or weakness may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

Senna and fertility

The product contains lactose monohydrate. One tablet contains 31.64 mg lactose monohydrate. Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine. Fertility, Pregnancy and Lactation: Consult a physician before use. There are no reports of undesirable or damaging effects during pregnancy or on the fetus associated with senna preparations when used in accordance with the recommended dosage schedule. However, as a consequence of experimental data concerning a genotoxic risk of several anthranoids (e.g. emodin and aloe-emodin), use is not recommended during pregnancy. Small amounts of active metabolites (rhein) are excreted in breast milk. A laxative effect in breast fed babies has not been reported. However, use during breast-feeding is not recommended as there is insufficient data on the excretion of metabolites in breast milk. Drug Interactions: There are no known drug interactions with sennosides. Intestinal loss of fluids may promote dehydration. Symptoms may include thirst and oliguria. In patients suffering from fluid loss where dehydration may be harmful (e.g. renal insufficiency, elderly patients) Senokot should be discontinued and only be restarted under medical supervision. Do not use different forms of senna (tablets, liquids, and others) at the same time or you could have an overdose.

The sugar moiety of the sennosides is removed by bacteria in the large intestine releasing the active anthrone fraction. This stimulates peristalsis via the submucosal and myenteric nerve plexuses.Senna has been used in alternative medicine as a possibly effective aid in emptying the bowel before a colonoscopy. Taking more than your recommended dose will not make this product more effective, and may cause serious side effects. appendicitis or symptoms of appendicitis (such as nausea/vomiting, sudden or unexplained stomach/abdominal pain) The product contains lactose monohydrate. One tablet contains 15.82mg lactose monohydrate. Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine. SENOKOT ® Tablets can be found at your local pharmacy and in many popular and convenient stores across Canada. Samples may be available through your family physician.